The midfielder went down off the ball and immediately appeared to be in distress, seeming to indicate a problem with his back.
After receiving treatment on the pitch, Keita was eased on to a stretcher and then driven off on the back of a buggy.
It is a disappointing blow for Keita, who is yet to make much of an impact following his big move from RB Leipzig.
Jordan Henderson took the 23-year-old’s place.
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