The Senegal international returns to the XI having been rested in the 4-0 victory over Bournemouth on Sunday, with Alex Oxlade-Chamberlain — back at his former club for the first time since his £35 million summer switch — held in reserve.
Emre Can joins Jordan Henderson in midfield having served a one-match ban for the totting up of yellow cards in the only other change to the 11.
Coutinho, meanwhile, marks his 150th league game for Liverpool.
Liverpool starting XI: Mignolet, Gomez, Lovren, Klavan, Robertson, Henderson, Can, Coutinho, Mane, Salah, Firmino
Liverpool subs: Karius, Alexander-Arnold, Milner, Wijnaldum, Lallana, Oxlade-Chamberlain, Solanke