Since losing his second professional fight in 2014, Lomachenko has 12 wins in as many bouts and represents a huge hurdle for challenger Campbell to attempt to clear.
So tough is the task ahead of Campbell that he last week told GQ he had been sparring three boxers at once to prepare.
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Does the home hopeful have any chance, or is Lomachenko simply too strong? Here’s a look at the tale of the tape:
VASYL LOMACHENKO
Born: 17/02/1988; Bilhorod-Dnistrovskyi, Ukraine Age: 31 Stance: Southpaw Height: 5ft 7ins Weight: 9st, 8lbs, 8oz Reach: 65.5ins Professional record: 13 wins, 1 defeat, 10 wins by knockout KO ratio: 71.4 per cent Major career titles: WBO featherweight; WBO super featherweight; WBA, WBO lightweight titles Last fight: Anthony Crolla, April 2019 (Won - KO)
LUKE CAMPBELL
Born: 27/9/1987; Hull, England Age: 31 Stance: Southpaw Height: 5ft 9ins Weight: 9st, 8lbs, 4oz Reach: 71ins Professional record: 20 wins, 2 defeats, 16 wins by knockout KO ratio: 72.7 per cent Major career titles: None Last fight: Adrian Yung, March 2019 (Won - TKO)